A DISRUPTED FOXP3 TRANSCRIPTIONAL SIGNATURE UNDERPINS SYSTEMIC REGULATORY T CELL INSUFFICIENCY IN EARLY PREGNANCY FAILURE

A disrupted FOXP3 transcriptional signature underpins systemic regulatory T cell insufficiency in early pregnancy failure

Summary: Regulatory T (Treg) cell defects are implicated in disorders of embryo implantation and placental development, but the origins of Treg cell dysfunction are unknown.Here, we comprehensively analyzed the phenotypes and transcriptional profile of peripheral blood Treg cells in individuals with early pregnancy failure (EPF).Compared to fertile

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Molecular aspects of tumor cell migration and invasion

Cell migration and invasion are crucial steps in many physiological events.However, they are also implicated in the physiopathology of many diseases, such as cancer.To spread through the tissues, tumor cells use mechanisms that involve several molecular actors: adhesion receptor families, receptor tyrosine kinases, photos de carhartt wip store toul

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Unveiling of brain transcriptome of masked palm civet (Paguma larvata) with chronic infection of Toxoplasma gondii

Abstract Background The aim of this study was to gain sugar skull pet odor candle an understanding of the transcriptomic changes that occur in a wild species when infected with Toxoplasma gondii.The masked palm civet, an artifically domesticated animal, was used as the model of a wild species.Transcriptome analysis was used to study alterations in

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